SYNTHESIS AND STUDY OF COMPLEX COMPOUNDS OF 3-AMINO-1,2,4-TRIAZOLE WITH SOME 3D METAL ACETATES
Keywords:
3-amino-1,2,4-triazole, raman spectrum, thermal analysisAbstract
Methods of synthesis of complex compounds of 3-amino-1,2,4-triazole with Co (II), Ni (II), Cu (II) and Zn (II) salts were elaborated, solubility of synthesized complex compounds in different solvents was studied. In order to determine the coordination centers of the ligand with the central atom, the IR spectra of the synthesized complex compounds were studied. According to the results of IR-spectroscopic research, it was found that the ligand is coordinated through the first nitrogen atom in the triazole ring in the reactions of 3-amino-1,2,4-triazole complex formation. The absorption bands characteristic of the acetate acid ligand indicate that acetate anions are connected to metals monodentately through an oxygen atom. And also the results of the IR spectra were confirmed by the Raman spectrum method. In the Raman spectrum, absorption associated with the M-N bond was observed in the region of 314, 438 cm-1. As a result of thermal analysis, the rate of decrease in the mass of the sample, the mass of decomposition of complexes, liquefaction, and the thermal stability of complexes and final products were determined. Thermogravigrams of thermolysis of the complexes show that mass loss begins at 150ºC and ends at 875ºC with the formation of metal oxides. The amounts of elements in the synthesized ligands and complexes were analyzed using the SEM-EDX method. On the obtained data of analysis, the percentage ratios of the masses of the elements in the complex were calculated. In the synthesized complex compounds, two 3-amino-1,2,4-triazole molecules and acidoligands were united in the monodentate state and formed complex compounds with a tetrahedral structure. According to the results of physical and chemical studies, it was found that metal and ligand are combined in a 1:2 ratio at the formation of complex compounds.
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Ali A., Al-Hassani R., Hussain D., Jabir M. Synthesis, spectroscopic, characterization, pharmacological evaluation, and cytotoxicity assays of novel nano and micro scale of copper (II) complexes against human breast cancer cells Meteab. Nano. Biomed. Eng. 2020.V.12. N 75. P.1-6
Mohammed I., Kummetha I.R., Singh G., Sharova N., Lichinchi G., Dang J., Stevenson M., Rana. J. 1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV 1 Vif Antagonists. Med. Chem. 2016.V. 59. P. 7677. DOI: 10.1021/acs.jmedchem.6b00247
Miceli, M. H., Kauffman, C. A. Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clinical Infectious Diseases. 2015 .V. 61. N 10. P.1558–1565 DOI:10.1093/cid/civ571
Zhang S., Xu Z., Gao C., Ren Q., Chang L., Feng L. Eur. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Based [1,2,4] Triazolo [4,3-c] quinazoline Derivatives.J. Med. Chem. 2017. V.138. P.501-513. DOI: org/10.1016/j.ejmech.2017.06.051
Shafi S., Alam M.M., Mulakayala N., Mulakayala C., Vanaja G., Kalle A.M., Pallu R., Alam M.S. Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities. Eur. J. Med. Chem. 2012. V. 49. P. 324-333. DOI: 10.1016/j.ejmech.2012.01.032
Ayati A., Emami S., Foroumadi A. Eur. The importance of triazole scaffold in the development of anticonvulsant agents. Eur.J. Med. Chem. 2016. V.109. P. 380-392. DOI: 10.1016/j.ejmech.2016.01.009
Narsimha S., Satheesh K.N., Kumara S.B., Vasudeva R.N., Althaf Hussain S.K., Srinivasa R.M. Indole-2-carboxylic acid derived mono and bis 1,4-disubstituted 1,2,3-triazoles: Synthesis, characterization and evaluation of anticancer, antibacterial, and DNA- cleavage activities. Bioorganic & Medicinal Chemistry Letters. 2016. V. 26(6). P.1639-1644. DOI:10.1016/j.bmcl.2016.01.055
Almeida A., Oliveira B.L., Correia J.D., Soveral G., Casini A. Emerging protein targets for metal-based pharmaceutical agents: An update. Coord. Chem. Rev. 2013.V. 257. N 19-20. P. 2689-2704. DOI:10.1016/j.ccr.2013.01.031
Mahapatra D.K., Bharti S.K., Asati V., Singh S.K. Perspectives of medicinally privileged chalcone based metal coordination compounds for biomedical applications. Eur.J. Med. Chem. 2019. V. 174. P.142-158. DOI: 10.1016/j.ejmech.2019.04.032
Ndagi U., Mhlongo N., Soliman M.E. Metal complexes in cancer therapy - an update from drug design perspective.Drug Des.Devel. Ther. 2017.V. 11. P. 599-616. doi: 10.2147/DDDT.S119488.
Kamal A., Syed M.A., Mohammed S.M. “Theraputic Potential of Benzothaizole” A Patent Review. Informa healthcare. 2015. V.25. N 3. P.335-349.
12. Singh A.K., Kandel K.R. Synthesis of Triazole Derivative: [4-benzylideneamino)-5-phenyl-
4H-1,2,4-triazole-3-thiol]. J. Nepal Chem. Soc. 2013.V. 30.doi:10.3126/jncs.v30i0.9391
Artemyev G.A., Ulomsky E.N., Rusinov V.L., Chupakhin V.N., Kopchuk D.S. Optimization of industrial methods for the production of 5-amino-3-mercapto-1,2,4-triazole and 5-amino-3-methylthio-1,2,4-triazole. Butlerov messages.2012. T.30. No. 6. P.70-80.
Артемьев Г.А., Уломский Е.Н., Русинов В.Л., Чупахин В.Н., Копчук Д.С. Оптимизация промышленных методов получения 5-амино-3-меркапто-1,2,4-триазола и 5-амино-3-метилтио-1,2,4-триазола. Бутлеровские сообщения.2012. Т.30. №6. С.70-80.
Hipler F., Winter M., Fischer A.R. N–S–H hydrogen bonding in 2-mercapto-5-methyl-1,3,4- thiadiazole. Synthesis and crystal structures of mercapto functionalised 1,3,4-thiadiazoles. 2003. V.658. N 3. P.179-191. DOI: 10.1016/S0022-2860(03)00386-7
Prishibl P. Complexes in chemical analysis. M.: ILL. 1960. P.175-304. (in Russian)
Пришибл П. Комплексоны в химическим анализе. М.: ИЛ. 1960. С.175-304.
Klimova V.A. Fundamentals of micromethod analysis of organic compounds. M: Chemistry. 1967. 19 p. (in Russian)
Климова В.А. Основы микрометода анализа органических соединений. М: Химия. 1967. 19 c.
Kalmykov K.B., Dmitrieva N.E. Scanning electron microscopy and X-ray spectral analysis of inorganic materials. Toolkit. Moscow. 2017. P.59.
Калмыков К.Б., Дмитриева Н.Е. Сканирующая электронная микроскопия и рентгено-спектральный анализ неорганических материалов. Методическое пособие. Москва. 2017. С.59.
Kumari M., Tahlan S., Narasimhan B.R., Ramasamy K., Lim S.M., Shah S.A., Mani V. and Kakkar S. Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scafolds as promising pharmacological agents. BMCChemistry. 2021. V.15. N 1. P.1-16. DOI.org/10.1186/s13065-020-00717-y
Tarasevich B.N. IR spectra of the main classes of organic compounds. Reference materials. Moscow: МSU.2012. P. 54 (in Russian)
Тарасевич Б.Н. ИК-спектры основных классов органических соединений. Справочные материалы. М.: МГУ. 2012. C. 54
Nakamoto K. IR and Raman spectra of inorganic and coordination compounds. Translation from EnglishMoscow: Mir. 1991. P. 536 (in Russian)
Накамото К. ИК-спектры и спектры КР неорганических и координационных соединений. Пер с англ. М.: Мир. 1991. C. 536
Kazitsyna L. A., Kupletskaya N. B. Application of UV, IR, NMR and mass spectroscopy in organic chemistry. Moscow: МSU. 1979. P. 240 (in Russian)
Казицына Л. Α., Куплетская Н. Б. Применение УФ-, ИК-, ЯМР- и масс-спектроскопии в органической химии. М. Изд-во МГУ. 1979. C. 240
Topor N.D., Ogorodova L.P., Melchakova L.V. Thermal analysis of minerals and inorganic compounds.Moscow: Mir. 1987. P. 190 (in Russian)
Топор Н.Д., Огородова Л.П., Мельчакова Л.В. Термический анализ минералов и неорганических соединений. М.: Изд-во МГУ. 1987. C.190
Kukushkin Yu.N., Khodzhaev O.F., Budanova V.F., Parpiev N.A. Thermolysis of coordination compounds.Т. Science. 1986. P. 198 (in Russian)
Кукушкин Ю.Н., Ходжаев О.Ф., Буданова В.Ф., Парпиев Н.А. Термолиз координационных соединений. Тошкент: Фан. 1986. C. 198
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