THE SIGNIFICANCE OF INTERLEUKIN 2 IN THE DEVELOPMENT OF MULTIPLE MYELOMA

Authors

  • Muxamadalieva Gulchexra Ph.D. head dept. transplantation Republican Specialized Scientific and Practical Center of Hematology, Uzbekistan

Keywords:

Multiple Myeloma, Interleukin 2 (IL-2), Cytokines

Abstract

Multiple myeloma (MM) is a malignancy characterized by the proliferation of plasma cells in the bone marrow. The pathogenesis of MM is complex and involves various cytokines, among which Interleukin 2 (IL-2) plays a critical role. This article aims to review the significance of IL-2 in the development and progression of MM. The focus will be on the molecular mechanisms by which IL-2 influences MM cell growth, survival, and interaction with the bone marrow microenvironment. Understanding the role of IL-2 in MM could provide insights into potential therapeutic strategies targeting this cytokine.

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References

Palumbo, A., & Anderson, K. (2011). Multiple Myeloma. New England Journal of Medicine, 364(11), 1046-1060.

Gordon, M. S., & Kantoff, P. W. (1991). Interleukin-2 and cancer therapy. Cancer Investigation, 9(5), 411-420.

Küppers, R., & Dalla-Favera, R. (2001). Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene, 20(40), 5580-5594.

Rossi, J. F., Lu, Z. Y., Jourdan, M., & Klein, B. (1991). Interleukin-6 as a therapeutic target. Clinical Cancer Research, 11(9), 314-324.

Trentin, L., Zambello, R., Sancetta, R., & Semenzato, G. (1999). Interleukin-2 receptor expression in hematologic malignancies. Leukemia & Lymphoma, 34(5-6), 401-411.

Caligiuri, M. A., & Trinchieri, G. (1995). Interleukin-2 and the biology of natural killer cells. Advances in Immunology, 60, 127-173.

Costello, R. T., Boehrer, A., Sanchez, C., Mercier, D., Baier, C., Le Treut, T., ... & Olive, D. (2004). Differential expression of natural killer cell activating receptors in blood versus bone marrow in patients with multiple myeloma. Haematologica, 89(5), 587-591.

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Published

2024-07-20

How to Cite

Muxamadalieva Gulchexra. (2024). THE SIGNIFICANCE OF INTERLEUKIN 2 IN THE DEVELOPMENT OF MULTIPLE MYELOMA. International Scientific and Current Research Conferences, 1(01), 102–105. Retrieved from https://www.orientalpublication.com/index.php/iscrc/article/view/1611