ASSOCIATION OF THE EDN1 LYS198ASN POLYMORPHISM WITH THE DEVELOPMENT OF CHRONIC TONSILLITIS
Keywords:
chronic tonsillitis, EDN1 gene, Lys198Asn polymorphismAbstract
Chronic tonsillitis is one of the most common inflammatory diseases of the lymphoid ring of the pharynx in both children and adults. In recent years, along with local infectious factors, increasing attention has been paid to hereditary predisposition and molecular genetic mechanisms involved in the development of this disease. The present study aimed to assess the significance of the biallelic Lys198Asn polymorphism of the EDN1 gene in the development of chronic tonsillitis and its clinical forms. The study included 94 patients aged 3 to 55 years diagnosed with chronic tonsillitis and 90 apparently healthy individuals without otorhinolaryngological diseases who served as the control group. Patients were classified into simple, toxic-allergic form I, and toxic-allergic form II. Molecular genetic analysis was performed using DNA isolated from peripheral blood lymphocytes, followed by real-time polymerase chain reaction for detection of the EDN1 (Lys198Asn) polymorphism.
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