DETERMINATION OF ACUTE TOXICITY D-38, KS-39 AND R-37 POLYSACCHARIDES

Authors

  • Raimova G.M Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Ortikov M.М Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Nasirov K.E Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Khoshimov N.N Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Madaminova G.А National University Of Uzbekistan, Tashkent, Uzbekistan
  • Abduraxmanov J.А Institute Of Bioorganic Chemistry Named After Academician A.S.Sadikov, Tashkent, Uzbekistan
  • Shodmonova D.Sh University Of Science And Technologies, Tashkent, Uzbekistan

Keywords:

polysaccharides, anticoagulant, thrombin time.

Abstract

In experiments the acute toxicity of D-38, KS-39 and P-37 sulfated polysaccharides with anticoagulant and antiaggregant properties was studied. From the obtained results, it was known that when D-38, KS-39 and P-37 polysaccharides were injected into the abdomen of animals at doses of 1000 and 2000, no death of animals was recorded during the entire experiment. At 4000 doses, death was observed in 1 out of 6 animals, i.e. 16.6% of animals. 50% mortality was observed in all mice when 5000 mg/kg of the above polysaccharides were administered intraperitoneally.

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References

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Published

2023-04-30

How to Cite

Raimova G.M, Ortikov M.М, Nasirov K.E, Khoshimov N.N, Madaminova G.А, Abduraxmanov J.А, & Shodmonova D.Sh. (2023). DETERMINATION OF ACUTE TOXICITY D-38, KS-39 AND R-37 POLYSACCHARIDES. International Scientific and Current Research Conferences, 1(01), 1–5. Retrieved from https://www.orientalpublication.com/index.php/iscrc/article/view/911

Issue

INTERNATIONAL CONFERENCE OF PHILOLOGY, SOCIAL ACTIVITIES AND MODERN SCIENCE

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Articles

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Copyright (c) 2023 Raimova G.M, Ortikov M.М, Nasirov K.E, Khoshimov N.N, Madaminova G.А, Abduraxmanov J.А, Shodmonova D.Sh

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