INFLUENCE OF EMODIN ON COAGULATION HEMOSTASIS

Authors

  • Khoshimov N.N. nstitute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Nasirov K.E. Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Ortikov M.M. Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Dedaboev J.I. Institute Of Biophysics And Biochemistry At The National University Of Uzbekistan Named After Mirzo Ulugbek, Tashkent, Uzbekistan
  • Akhtamov M.A. National University Of Uzbekistan, Tashkent, Uzbekistan
  • Khodjiev S.S. National University Of Uzbekistan, Tashkent, Uzbekistan
  • Kozokov I.B. National University Of Uzbekistan, Tashkent, Uzbekistan
  • Abdurakhmonov Zh.A Institute Of Bioorganic Chemistry Named After Academician A.S.Sadikov, Tashkent, Uzbekistan
  • Mukhtorov A.A. Namangan State University, Uzbekistan
  • Mamadaminov R.R. Namangan State University, Uzbekistan
  • Eshbakova K.A. Institute Of Chemistry Of Plant Substances. Tashkent, Uzbekistan

Keywords:

Alkaloid, activated partial thromboplastin time (APTT), prothrombin time

Abstract

The alkaloid emodin was studied in coagulation hemostasis of blood in rats in vitro. The results show that Emodin prolongs prothrombin time and aPTT more effectively, but does not affect thrombin time. At the same time, prothrombin time and APTT were prolonged up to a certain dose (50 µg/ml). These results may indicate the inhibition of one of the factors II, V, VII, and X of coagulation hemostasis.

Downloads

Download data is not yet available.

References

Nozim N. Khoshimov, Alisher A. Mukhtorov, Kabil E. Nasirov, Rakhmatillo N. Rakhimov, & Rahmatjon R. Mamadaminov. (2022). Effeсts оf Pоlyphenоls оn Сhаnges in the Trаnspоrt оf Са2+ NMDА-reсeptоrs Under the Influenсe оf L-glutаmаte аgаinst the Bасkgrоund оf Аlzheimer’s Diseаse. Journal of Pharmaceutical Negative Results, 1322–1332. (Q4) CiteScore (1). Retrieved from https://www.pnrjournal.com/index.php/home/article/view/1203

Alisher A. Mukhtorov, Rahmatjon R. Mamadaminov, Nozim N. Khoshimov, Kabil E. Nasirov, Rakhmatilla N. Rakhimov, Lutpillaev X. Gaybullo. Regulation of transport of Ca2+ NMDA-receptors in rat brain synaptosomes under the influence of polyphenols. European Journal of Medicine. 2022. 10(1): 3-11.

Khoshimov N.N., Ortikov M.M., Dedaboev J.I., Nasirov K.E., Ashirmatova N.M., Khasanova Kh.I., Eshbakova K.A. Influence of emodin on plasma hemostasis. Инфекция иммунитет и фармакология. Спец. Вып. Ташкент. №3.2022.С.275-283.

Khоshimоv N.N., Mamatova M.Sh., Ortiqov M. M., Mukhtorov A.A., Mamadaminov R.R., Eshonov M.A. Changes in thrombin time in the blood plasma of rats under the influence of Acuzun. XXV Anniversary International Biomedical Conference of Young Researchers «Fundamental Science and Clinical Medicine - Homo and Health». St. Petersburg State University. 2022. P.408-409.

Khоshimоv N.N., Mamatova M.Sh., Ortiqov M. M., Eshonov M.A. Study of the effect of alkaloid acuzun on the platelet aggregation of the blood plasma of patients with coronary heart disease. XXV Anniversary International Biomedical Conference of Young Researchers «Fundamental Science and Clinical Medicine - Homo and Health». St. Petersburg State University. 2022. P.412-413.

Ortiqov M. M., Khоshimоv N.N., Rakhmonova N. Sh., Musaeva M.K., Nasirov K.E. Study of the influence of biologically active compounds on the coagulation of the blood plasma of rats with the help of venom vipera lebetina. XXV Anniversary International Biomedical Conference of Young Researchers «Fundamental Science and Clinical Medicine - Homo and Health». St. Petersburg State University. 2022.P. 414-415.

Downloads

Published

2023-03-20

How to Cite

Khoshimov N.N., Nasirov K.E., Ortikov M.M., Dedaboev J.I., Akhtamov M.A., Khodjiev S.S., Kozokov I.B., Abdurakhmonov Zh.A, Mukhtorov A.A., Mamadaminov R.R., & Eshbakova K.A. (2023). INFLUENCE OF EMODIN ON COAGULATION HEMOSTASIS. International Scientific and Current Research Conferences, 1(01), 89–92. Retrieved from https://www.orientalpublication.com/index.php/iscrc/article/view/900

Issue

VITAL ISSUES OF MODERN SCIENTIFIC RESEARCH

Section

Articles

License

Copyright (c) 2023 Khoshimov N.N., Nasirov K.E., Ortikov M.M., Dedaboev J.I., Akhtamov M.A., Khodjiev S.S., Kozokov I.B., Abdurakhmonov Zh.A, Mukhtorov A.A., Mamadaminov R.R., Eshbakova K.A.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The content published on the International Scientific and Current Research Conferences platform, including conference papers, abstracts, and presentations, is made available under an open-access model. Users are free to access, share, and distribute this content, provided that proper attribution is given to the original authors and the source.

Most read articles by the same author(s)